Triple Helix Discovery Engine
Triple Helix Framework
Industry
Architects: Small & Medium Size Business (SMBs), Product Development, De-Risking, Validation, Building Niche & Emerging Markets
*Architects: Biotechnology_Personalized, Precision, Preemptive Medicines
Nested Therapeutics

Organization & Developments: Nested Therapeutics

Parents

2022: Nested co-founders include Kevan Shokat, the scientist whose team published the groundbreaking paper in 2013 detailing how KRAS, once thought undruggable, could be targeted and paved the way for Amgen’s Lumakras, which got FDA approval last year for lung cancer with the mutation.
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Process is investigating and screening protein structures, using information from the Protein Data Bank to find driver mutations, isolate the mechanism behind those mutations and then identify ways to target those mutations.