MedTechIQ_3Helix InSight Engine-Beta
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Triple Helix Discovery Engine
*Driving Forces: Market Research, Intelligence, Analysis, Datapoints, Databases & Trends
*Driving Forces: BioPharmaceuticals _ Biotechnology, Genomics, Genetics, Bioinformatics, Biomanufacturing & Personalized Medicine
*Biotechnology: Key Issues
*Key Terms: Biotechnology
Genomics, Genetics & Gene Therapy
Parents
*Key Terms: Biotechnology
BioTechnology
Medical Science & Technology
Personalized & Precision Medicine
Children
"Physiome Project,"
**Key People: MVP (Million Veteran Program)
*All of Us ... formerly, Precision Medicine Initiative (PMI)
*Full genetic complement of an organism (DNA), relatively static over time
*Funding: Biotechnology_Genome, Genomics, Genetics, Gene Editing & Therapy, MultiOmics, Personalized & Precision Medicine
*Funding: Genomics, Genetics, Personalized & Precision Medicine (Archives 2014-2016)
*Funding: Genomics, Genetics, Personalized & Precision Medicine Archives (2017)
*Funding: VA_MVP (Million Veteran Program)
*ICB (Institute of Collaborative Biotechnology): Industrial Partners
*Key People: Children's Hospital of Philadelphia (CHOP)
*Key People: ICB (Institute of Collaborative Biotechnology)
*Key People: ISB
*Key People: NFGC-National Functional Genomics Center
*MVP (Million Veteran Program), VA
*Organization & Developments: MVP (Million Veteran Program)
*Pioneers: Biotechnology_Genomics
*Pioneers: Biotechnology_Personalized Care, Precision Medicine, Genomics & Genetics
*Pioneers: Genomics (Research Centers & Programs)
#3:FY 2009 AUTM Hospital License Income = $198,249,946 (Children's Hospital of Philadelphia-CHOP)
$40m over thre years
1) Breast Cancer Risk Reduction
100,00 DNA profiles
2) Genomics, Proteomics, and Immunology Research
2011: DNA Sequencing Caught in Deluge of Data (2011)
2011: eMERGE Funding to Expand (2011)
2011: Inova's genomics project taking shape (2011)
2014: Geisinger, NIH launch online genomic patient portal
2014: Global Genomics Harmony
2014: MedImmune, pharma giants launch joint genomics-based lung cancer trial
2014: New York State-Initiated $105 Million Collaboration to Advance Genomic Medicine (2014)
2014: NIH awards $14.5 million to research groups studying newest DNA sequencing techniques
2014: NIH awards two new grants to explore the understanding of genomics research in Africa
2014: Northrop Grumman wins $27M contract to maintain pathogen websites
2014: RFA-DK-14-003: Accelerating Medicines Partnership (AMP) in Type 2 Diabetes (U01) = $3,000,000/10 - Jul 18, 2014
2014: U.S. Army Recognizes Institute's Sweeping Advances in Biotechnology with $48 Million Contract Renewal
2014: UC Berkeley Receives $10 Million for Genomic Engineering Initiative
2015: 100,000 Genomes Project taps Big Pharma dream team for data crunching skills
2015: Air Force Patients to Receive Genetic Information
2015: Amgen's deCODE lays marker for future of genomics-driven drug discovery
2015: George Church backs online platform for open sharing of personal data
2015: NIH Funds Support eMERGE
2015: PrecisionFDA platform opens to the public
2015: Simons Foundation Awards $1 Million for Human Genome Variation Map
2015: VA Initiating New MVP Studies
2016: HHS FY 2017 Budget Highlights_federaltelemedicine
2016: IBM Donates Use Of Watson To Veterans Health System As Part Of Biden's Cancer Moonshot_forbes
2016: Johns Hopkins applies physics and engineering to precision medicine
2016: Lockheed to Support Military Veteran Genomics Project; Horace Blackman Comments
2016: NHLBI Federal Researchers Build Massive Online Database of Genomic Data
2016: NIH commits $313M over four years to sequencing genomics of human disease
2016: NIH funds Mayo Clinic biobank to support Precision Medicine Initiative Cohort Program_nih
2016: NIH funds new studies on ethical, legal and social impact of genomic information_nih
2016: NIH Raises TSRI Funding to $200M toward PMI Enrollment Effort
2016: NIH-NIDA-RFA-DA-15-006: Avenir Award Program for Genetics or Epigenetics of Substance Abuse (DP2)=$1,500,000x2-3-Due Dates:August 18, 2014, August 18, 2015, August 18, 2016
2016: NY Genome Center enlists IBM to create Watson-enabled cancer research platform
2016: ONC’s FHIR Sync for Science (S4S) Pilot for Precision Medicine
2016: Precision medicine, Blue Button high priorities in Open Government plan
2016: Significant expansion of data available in the Genomic Data Commons
2016: VA, Flow Health unveil 5-year deep learning, precision medicine partnership_VA to build "medical knowledge graph"
2016: VA, NIH Eye Improved Clinical Outcomes With Big Data Scientist Training Program – Executive Gov
2016: VA's David Shulkin: Million Veterans Program a boon to Precision Medicine, Moonshot initiatives
2016: Verily, Vanderbilt to test enrollment in U.S. Precision Medicine pilot
2016: With 500,000 participants, VA says it has world’s top genomic database
2017: Alphabet seeks 10,000 volunteers — and their health data — for a massive medical study
2017: CDC_Nanopore Technologies
2017: Illumina & IBM Watson form cancer genomics partnership
2017: Illumina Introduces New Sequencers to Help Reduce Whole Genome Analysis to $100
2017: VA-Q--Genomic Sequencing_MVP
2018: Nebula Genomics, with free DNA sequencing, opens for business
2018: NHGRI_Investigator-Initiated Genomic Medicine Research (R01 Clinical Trial Optional)
2018: NHLBI_A--Trans-Omics for Precision Medicine (TOPMed) Inform
2018: NHLBI_Gene Therapy Resource Program (GTRP)_University of Pennsylvania
2018: NHLBI_National Gene Vector Biorepository and Coordinating Center(NGVB)_Indiana University
2018: NIH STRATEGIC PLAN FOR DATA SCIENCE_datascience.nih.gov
2018: NSF_19-527_Enabling Discovery through GEnomic Tools
2018: USAMRMC_ICD Next Generation Sequencing Services
2019: CDC-RFA-DP19-1905 _ The CDC Cancer Genomics Program: Translating Research into Public Health Practice
2019: Chan Zuckerberg Initiative Awards $68 Million for Human Cell Atlas
2019: ESMO: Grail's multi-cancer blood test expands data in over 20 disease types
2019: FDA_FY 2019 precisionFDA, Collaborative Omics Environment in the Cloud Indefinite Delivery/ Indefinite Quantity (IDIQ)
2019: FDA_Human Whole Genome Sequencing Service
2019: FDA_Sequencing (16) Genomic DNA samples from cancer patients
2019: FDA_Targeted Gene Sequencing
2019: Gene Therapy/Editing Series 1: A Brief Introduction To Gene Therapy_seekingalpha.com
2019: NCI_A Public Health Genomics Approach to Cancer Etiology and Risk Estimation
2019: NCI_Genomic Characterization Centers
2019: NHGRI_High Quality Human Reference Genomes (HQRG) (U01 Clinical Trial Not Allowed)
2019: NHGRI_NOIP_Centers for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry (U01 Clinical Trial Not Allowed)
2019: NHGRI_RFA-HG-19-003 _ Research and Development for Genome Reference Representations (GRR) (U01 Clinical Trial Not Allowed)
2019: NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)
2019: NHLBI_DNA & RNA Sequencing Services Requested
2019: NIAID_comprehensive epigenomics Services.
2019: NIAID_CUSTOM GENETIC SEQUENCING_GeneWiz
2019: NIAID_Genomic Sequencing Services for the NIAID Centralized Sequencing Initiative
2019: NIAID_RNA Sequencing Service_U of Florida
2019: NIH_NCATS_Whole Genome CRISPR Screen
2019: NIH_NIA_DNA and RNA Sequencing of parental iPSC cell lines
2019: NIH_RFA-HG-19-013: The Electronic Medical Records and Genomics (eMERGE): Genomic Risk Assessment and Management Network
2019: NIH_RFA-HG-19-015: The Electronic Medical Records and Genomics (eMERGE): Genomic Risk Assessment and Management Network
2019: NINDS Human Genetics Resource Center
2019: NINDS Human Genetics Resource Center
2019: R--NHGRI Community Engagement Toolkit
2019: U.S. Army_MEDCOM_Whole Genome and Metagenomics Sequencing Project
2019: U.S. Army_MEDCOM_Whole Genome and Metagenomics Sequencing Project
2019: U.S. Navy_BUMED_Next Generation Sequencing System
2019: U.S. Navy_BUMED_Single Gene Genetic Testing
2019: VA_J--MVP research VA central Biorepository
2019: VA_Q--Genomic Sequencing Services_Foundation Medicine
2019: VA_R--SOURCES SOUGHT NOTICE: Computational Capabilities for Whole Genome Sequences
2019: VA_Y--MVP Biorepository
2020: All of Us Research Program - National, State, and Local Engagement Partner Funding Opportunity (OT2)
2020: Mayo Clinic to create patient genetic data library
2020: NCI_Genomic Data Analysis Network: Genomic Data Analysis Center (U24 Clinical Trial Not Allowed)
2020: NCI_RFI_Pediatric preclinical models (cell lines and patient-derived xenografts) for which genomic characterization will enhance research value
2020: NHGRI_NOIP_Coordinating Center for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry (U01 Clinical Trial Not Allowed)
2021: All of Us building Researcher Workbench, a cloud-based analytics platform, with its back end, an open-source system called Terra
2021: Burroughs Wellcome Fund Invites Applications for Career Awards at the Scientific Interface
2021: CRISPR-Based Spit Test Detects SARS-CoV-2 and Variants
2021: NCI_RFI_Seeking Input on Technology Needs for Cancer Control and Population Sciences Researchers
2021: NHLBI_RFA-HL-20-022: Enabling Technologies and Transformative Platforms for HLBS Research (R33
2021: NIH_NIDCR_Feasibility Studies that Explore Healthy and Diseased Temporomandibular Joints (TMJ) using Single Cell Multi-Omic Analyses (UH2/UH3 Clinical Trial Not Allowed)
2021: NIH_NOIP_Nutrition for Precision Health, powered by the All of Us Research Program: Research Coordinating Center (U24 Clinical Trial Not Allowed)
2021: NIMH_From Genomic Association to Causation: A Convergent Neuroscience Approach to Linking Levels of Analysis for Understanding Neuropsychiatric Disorders (U19 Clinical Trial Optional)
2021: OIG: Gaps in CMS ERM Puts Genomic Data Security at Risk
2021: UCLA Health receives $29 million in support of genetic research
2021: UCLA Receives $4.8M NIH Grant to Improve Genetic Risk Estimates
2022: NASEM_Use of Race, Ethnicity, and Ancestry as Population Descriptors in Genomics Research
2022: NIAID_SUNBEAM - Analysis and Bioinformatics Center (ABC) (UM1 Clinical Trial Not Allowed)
2022: NIH_NOIP_IND-enabling Studies of Somatic Genome Editing Therapeutic Leads (U19, Clinical Trial Not allowed)
2022: NIH_NOIP_Somatic Cell Genome Editing Translational Coordination and Dissemination Center (U24, Clinical Trial Not Allowed)
2022: NIH_NOIP_Technologies and Assays for Therapeutic Genome Editing INDs (U01, Clinical Trial Not Allowed)
2022: NIH_RFI: Proposed Updates and Long-Term Considerations for the NIH Genomic Data Sharing Policy
2022: NIMH_NOIP_Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes: Data Resource and Administrative Coordination Center (U24 Clinical Trial Not Allowed)
2022: NINDS_NOIP_HEAL Initiative: Discovery and Functional Evaluation of Human Pain-associated Genes & Cells (U19 Clinical Trial Not Allowed)
2022: NINDS_NOIP_HEAL Initiative: Human Pain-associated Genes & Cells Data Coordination and Integration Center (U24 Clinical Trial Not Allowed)
2023: NHGRI_New Investigators to Promote Workforce Diversity in Genomics and other Health-Related Research (R01 Clinical Trial Optional)
2023: NHGRI_NOSI: Short-term Mentored Research Career Enhancement Award to Promote Genomic Medicine Diversity
2023: NHGRI_Technology Development for Single-Molecule Protein Sequencing (R43/R44 Clinical Trial not allowed)
2023: NHLBI_NOSI: Integrative Omics Analysis of NHLBI TOPMed Data (Parent R01 Clinical Trial Not Allowed)
2023: NIAID_New Technologies for the In vivo Delivery of Gene Therapeutics for an HIV Cure (R01 Clinical Trial Not Allowed)
2024: NHGRI_Genomic Curriculum Development for Medical Students (R25 Clinical Trial Not Allowed)
2024: NHGRI_Investigator Initiated Research in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)
2024: NHGRI_Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)
2024: NHGRI_New Investigators to Promote Workforce Diversity in Genomics, Bioinformatics, or Bioengineering and Biomedical Imaging Research (R01 Clinical Trial Optional)
2024: NHGRI_NOSI: Methods Development for Genomic Studies of Genetic Variation, Function, and Disease
2024: NHGRI_Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)
2024: NIA_NOSI_Genetic Underpinnings of Endosomal Trafficking as a Pathological Hub in Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD)
2024: NIAAA_NOSI_Genetics of Alcohol Sensitivity and Tolerance
2024: NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)
2024: NIGMS National and Regional Resources (R24
2024: NIH_NOSI: Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research
2025: *Precision Medicine Software Market projected to reach $5.66 billion by 2033 at a CAGR of 11.8%
2025: NHGRI_NOSI_Development and Implementation of Clinical Informatics Tools to Enhance Patients Use of Genomic Information
2025: NIAID_NOSI: Molecular and Genetic Characterization of Inborn Errors of Immunity
2025: NIAID_NOSI: Molecular and Genetic Characterization of Inborn Errors of Immunity
2025: NICHD_Screening and Functional Validation of Human Birth Defects Genomic Variants (R01 Clinical Trial Not Allowed)
29 private clinics
3) Biorepository
4) Biomedical Informatics
5) Clinical Care.
Abeona Therapeutics Inc. (NASDAQ: ABEO)*
Advanced Electron Microscopy
Algorithms for remote life-sign detection
Amicus Therapeutics, Inc (NASDAQ: FOLD)*
Analysis of prehospital trauma data
Anonymous database
Ariosa Diagnostics
Automated DNA Sequencer
AveXis (NASDAQ:AVXS)
BGI (Beijing Genomics Institute)-Shenzhen
BIC-BioInformatics Cell, TATRC, DOD
BioBank
Biomedical Informatics Training Program
Bioscience for Energy
Brian Barnes
Butte Lab
CBCR:Center for Biomedical Computaions Research
Cell and Gene Therapy (CGT)
Center for Applied Genomics
Center for Genomics and Bioinformatics
Child Injury Prevention Studies (CChIPS) (updated Mar 2010) Children's Hospital of Philadelphia
Children's Hospital of Philadelphia (CHOP).
CHOP's Harvest Toolkit Offers Innovative Data Discovery Resource for Biomedical Researchers (2013)
Collecting and analyzing detailed DNA profiles on as many as 100,000 patients
Complete Genomics (NASDAQ: GNOM)
Complete Genomics Inc to be Bought by Chinese Firm (2012)
Complete Professional Liability Insurance Application
Comprehensive Cardiac Genomic Database
Comprehensive Reproductive System Care Program (CRSCP) - WRI/WRAMC/HJF
Computational Proteomics-MHPCC
Computer Science
Concept Based Search & Retrieval
Coriell Institute for Medical Research - About Coriell
Develop new technologies in molecular medicine to advance the early detection, diagnosis, and treatment of cancer and other chro
Development of a Multileaf Collimator for Proton Radiotherapy - U of Pa
DiscovEHR_50,000-person genomics study reveals untapped medical potential
Dr Atul Butte, MD, Phd, Priscilla Chan and Mark Zuckerberg Distinguished Professor at the UCSF School of Medicine (2017)
Dr Lawrence Fagan, MD, PHD, Co-Director, Biomedical Informatics Training Program,Stanford University
Dr Lorraine Frazier, UTHSC
Dr Peter Cherbas-Director/Co-Director, MetaCyte
Dr Ronald Przygodzki, MD, VA Associate Director, Genomic Medicine (2016)
Dr S. Ward Casscells, III, MD, former, Assistant Secretary of Defense, Health Affairs-UTHSC
Dr W. Jackson Pledger, Phd, Director, NFGC, Deputy Director, Moffitt Cancer Center
Dr. James T. Willerson, President & Medical Director of the Texas Heart Institute & CEO, UTHSC
Dr. Richard K. Wilson, Genome Institute, Washington University
E. David Litwack, Ph.D. Personalized Medicine Staff Fellow, Food and Drug Administration (FDA)-2016
Ecosystem Interrogation
eMERGE (Electronic Medical Records and Genomics) Network
Emerging Technology Center-Indiana U
Epigenomics, Epigenetics
Extension of gene analysis tools to military relevant animal models (C. elegans and rats)
Fastest Growing - CY 2004/2005
Finance & Acquisition: ISB
Founded 2001
Founded 2009
Gene
Gene Editing
Gene Writing
Genelex
Genetics
Genome
Genome Institute, Washington University
Genomic database - novel and unique for identifying genes/environment-gene interactions that lead to cardiovascular diseases/can
Genomics
Genomics / Proteomics, TATRC
Genomics Core (Cardiology)-T5/UTHSC
George Church, Serial Co-Founder and Chief Scientific Advisor (2025)
Global Alliance for Genomics and Health (GA4GH)
Glycomics
Hakon Hakonarson, Director
HealthMaps, visual tools designed to provide information in a map format to help users navigate through the many different aspec
Hibernation Genomics-University of Alaska
HUI: Bioinformatics - Genomics Research Project
ICB (Institute for Collaborative Biotechnologies), UCSB
ICB: Academic Partners
ICB: Mission
ICB: Objectives
Imaging
Indiana Genomics Center
Indianapolis, Indiana
Inproteo
InProteo, through its spin-off company Omni Spray , is developing technology using novel mass spectrophotometric techniques.
International Genomics Consortium
ISB (Institute of Systems Biology)
It aims to develop integrative models at all levels of biological organization, from genes to the whole organism via gene regu
Joint Institue for Biological Sciences
Keck Foundation Awards $1 Million to University of Wisconsin-Madison for Genome Research (2012)
Lipidomics
Machine-learning algorithms for characterization of protein
Mark Carlson, MD, Director, SNCC
Mark Long, CEO, IURTC
MedGenome Inc.
Medical taxonomies to organize content
Metabolic Disease, Metabolomics, Metabolic Health
MetaCyte
MetaThesaurus
Methods for differential diagnosis of DNA microarray studies
Microbiomics, Microbiome
Mission of Supporting the Development of Science and Technology, Building Strong Research Teams, and Promoting the Development of Scientific Partnership in Genomics Field.
Models for predicting individual soldier performance
Molecular diagnosis may be better than a diagnosis based on just what the tumor looks like
Molecular Machines - Functional
Mouse Genetics
National Functional Genomics Center (NFGC):Research Areas
NeuMoDx
New York Genome Center (NYGC)
NFGC-National Functional Genomics Center (Bill and Beverly Young)-USF
NFGC-National Functional Genomics Center-SNCC-Southeast Nebraska Cancer Center)
NFGC:External Advisory Board
NFGC:Objectives
NFGC:Partners
Oldest pediatric hospital
Ontologies
Open Humans
Organisms whose cells are organized into complex structures enclosed within membranes.
Organization & Developments: ISB
Part of a larger TexGen project
Personal Genome Project
Philadelphia, Pennsylvania
Plans to add 3,000 jobs and spend $1.7b over the next 5 years (2006)
pre-symptomatically screen these patients for genomic variability
Proteomics
Seattle, Washington
Shenzhen, Guangdong, China
Simulation
Software for analysis of 2D mass spectrometer data
Stanford Medical Informatics Affiliates Program
Statistical methods for analysis of DNA microarray data
Subsurface Science
T. Denny Sanford Gives $125 Million to Establish Genomic Initiative for Internal Medicine (2014)
Tempus Labs, Inc.
TGEN-Translational Genomics Research Institute
The DESI technology developed by Omni Spray is unique and has multiple applications for the accurate detection of explosive devi
The development of this space will include purchase of a variety of equipment and the development of the IUETC facility to facil
The Indiana University Emerging Technologies Center functions as a business incubator for life and health sciences companies.
The Indiana University Research & Technology Corporation (IURTC), owner of the IUETC, is Indiana University s active partner in
The IUETC forms, develops and grows technology businesses.
The IUETC seeks to provide quality laboratory space and equipment to further the research for these companies to develop their p
Theresa Peterson, Government Relations, General Electric, Board of Directors, MTEC (2018)
Transcriptome, Transcriptomics
Translation Genomics Research Institute
Translation Medicine
VA_DEAN_Task 2. Advanced Clinical Decision Support and Data-Driven Decision Making in Healthcare
We need to pay attention to the molecular changes that give rise to cancer
Web-based physiologic data management and analysis system
Wendy Rubinstein, MD, PhD, Director, NIH Genetic Testing Registry and Senior Scientist, National Institutes of Health, (NIH)-2016
Will contain information on 500,000 genetic markers
Will validate the concept that molecular signatures in tumors predict cancer risk, diagnosis, prognosis, and response to therapy
Worldwide public domain effort to provide a computational framework for understanding human and other eukaryotic physiology
WuXi NextCODE (WXNC)