GPR18

N-arachidonyl glycine receptor also known as G-protein coupled receptor 18 (GPR18) is a protein that in humans is encoded by theGPR18 gene.^[1][2] Along with the other previously "orphan" receptorsGPR55 and GPR119, GPR18 has been found to be a receptor for endogenous lipid neurotransmitters, several of which also bind tocannabinoid receptors.^[3][4][5]

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Recent research supports the hypothesis that GPR18 is the abnormal 

cannabidiol receptor and N-arachidonoyl glycine, the endogenous lipid metabolite of anandamide, initiates directed microglial migration in the CNS through activation of GPR18.^[6]