Alzheimer's disease
<p>Niacinamide is an activator of <a href="http://en.wikipedia.org/wiki/Sirtuins" title="Sirtuins" class="mw-redirect" >sirtuins</a> (but inhibits at higher doses) and has been reported to restore cognition in <a href="http://en.wikipedia.org/wiki/Alzheimer%27s_disease" title="Alzheimer's disease" >Alzheimer's disease</a> transgenic mice.<sup id="cite_ref-10" class="reference" ><a href="http://en.wikipedia.org/wiki/Niacinamide#cite_note-10" >[11]</a></sup>
A safety study of niacinamide for the treatment of Alzheimer's disease is currently underway at the University of California, Irvine.<sup id="cite_ref-11" class="reference" ><a href="http://en.wikipedia.org/wiki/Niacinamide#cite_note-11" >[12]</a></sup>
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