Frankincense, Oil

In a study published in 2009, it was reported that "Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability."<a href="http://en.wikipedia.org/wiki/Frankincense#cite_note-23">[23]</a>

A 2012 study in healthy volunteers determined that exposure to 11-keto-β-boswellic acid (KBA), a lead boswellic acid in the novel solubilized frankincense extract <a href="http://en.wikipedia.org/w/index.php?title=Boswelan&action=edit&redlink=1" class="new" title="Boswelan (page does not exist)">Boswelan</a>, is increased when taken with food. However, simulations based on a two-compartment pharmacokinetic model with single first-order absorption phase proposed that the observed food interaction loses its relevance for the simulated repeated-dose scenario.<a href="http://en.wikipedia.org/wiki/Frankincense#cite_note-24">[24]</a>

In a 2012 study, researchers found that the "behavioral effect [of insensole actetate] was concomitant to reduced serum corticosterone levels, dose-dependent down-regulation of corticotropin releasing factor and up-regulation of brain derived neurotrophic factor transcripts IV and VI expression in the hippocampus.

These data suggest that IA modulates the hypothalamic–pituitary–adrenal (HPA) axis and influences hippocampal gene expression, leading to beneficial behavioral effects supporting its potential as a novel treatment of depressive-like disorders."<a href="http://en.wikipedia.org/wiki/Frankincense#cite_note-25">[25]</a>