5-Hydroxytryptophan
<p>5-HTP is sold <a href="http://en.wikipedia.org/wiki/Over-the-counter" title="Over-the-counter" class="mw-redirect">over the counter</a> in the <a href="http://en.wikipedia.org/wiki/United_Kingdom" title="United Kingdom">United Kingdom</a>, <a href="http://en.wikipedia.org/wiki/United_States" title="United States">United States</a> and <a href="http://en.wikipedia.org/wiki/Canada" title="Canada">Canada</a> as a <a href="http://en.wikipedia.org/wiki/Dietary_supplement" title="Dietary supplement">dietary supplement</a> for use as an <a href="http://en.wikipedia.org/wiki/Antidepressant" title="Antidepressant">antidepressant</a>, <a href="http://en.wikipedia.org/wiki/Appetite_suppressant" title="Appetite suppressant" class="mw-redirect">appetite suppressant</a>, and <a href="http://en.wikipedia.org/wiki/Sleep_aid" title="Sleep aid" class="mw-redirect">sleep aid</a>, and is also marketed in many European countries for the indication of <a href="http://en.wikipedia.org/wiki/Major_depression" title="Major depression" class="mw-redirect">major depression</a> under trade names like <b>Cincofarm</b>, <b>Levothym</b>, <b>Levotonine</b>, <b>Oxyfan</b>, <b>Telesol</b>, <b>Tript-OH</b>, and <b>Triptum</b>.<sup id="cite_ref-pmid15893130_1-0" class="reference"><a href="http://en.wikipedia.org/wiki/5-Hydroxytryptophan#cite_note-pmid15893130-1">[1]</a></sup><sup id="cite_ref-isbn3-88763-075-0_2-0" class="reference"><a href="http://en.wikipedia.org/wiki/5-Hydroxytryptophan#cite_note-isbn3-88763-075-0-2">[2]</a></sup> </p>
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Several <a href="http://en.wikipedia.org/wiki/Double-blind" title="Double-blind" class="mw-redirect">double-blind</a> <a href="http://en.wikipedia.org/wiki/Placebo" title="Placebo">placebo</a>-controlled <a href="http://en.wikipedia.org/wiki/Clinical_trial" title="Clinical trial">clinical trials</a> have demonstrated the effectiveness of 5-HTP in the treatment of depression,<sup id="cite_ref-pmid15893130_1-1" class="reference"><a href="http://en.wikipedia.org/wiki/5-Hydroxytryptophan#cite_note-pmid15893130-1">[1]</a></sup> though a lack of high quality studies has been noted.<sup id="cite_ref-pmid11687048_3-0" class="reference"><a href="http://en.wikipedia.org/wiki/5-Hydroxytryptophan#cite_note-pmid11687048-3">[3]</a></sup> More and larger studies are needed to determine if 5-HTP is truly effective in treating depression.<sup id="cite_ref-4" class="reference"><a href="http://en.wikipedia.org/wiki/5-Hydroxytryptophan#cite_note-4">[4]</a></sup></p>