Open in TheBrain

LIFUS Params

ParameterDefinitionRange (LIFU)
Frequency (f)Carrier ultrasound frequency0.25 – 5 MHz
Intensity (Ispta)Spatial-peak temporal-average intensity0.1 – 500 mW/cm²
IsppaSpatial-peak pulse-average intensity1 – 100 W/cm²
Pressure amplitude (P)Peak negative acoustic pressure0.01 – 1 MPa
Duty Cycle (DC)Fraction of time ultrasound is ON (ton / T)0.1% – 100%
Pulse Repetition Frequency (PRF)Rate of pulse envelope repetition10 – 3000 Hz
Pulse Duration (PD)Duration of a single ON burst0.1 – 100 ms
Sonication Duration (SD)Total duration of the stimulation train50 ms – 80 s
Burst DurationDuration of a single ultrasonic burst within a pulse0.02 – 10 ms
Number of cycles per burstAcoustic cycles within one burst5 – 10,000
Mechanical Index (MI)Cavitation risk proxy: P / √f< 0.73 (FDA limit)
Thermal Index (TI)Estimated tissue temperature rise proxy< 1 (neuromodulation)
Center frequencyPrimary resonant frequency of the transducer0.25 – 2.25 MHz (CNS)