senescent cells

Parents

"A pill or an injection that would clean out senescent cells throughout your entire body would be a brilliant future but we have to be very careful."
(One complication with senescent cells is that because they all spring from different normal cell types they retain their own individuality, a drug might kill senescent skin cells, fat cells or blood vessel cells but is unlikely to kill all three.)
2011 Jan van Deursen and colleagues at the nonprofit medical organisation the Mayo Clinic showed that eliminating senescent cells in mice via a genetic trick delayed some of the ravages of age in prematurely aged mice.
Cleara's approach, meanwhile, which uses an engineered peptide molecule, targets a particular subtype of senescent cell, which, says scientific co-founder Peter de Keizer, will make it safer.
Kirkland, who is also running a handful of clinical trials at Mayo for repurposed cancer drugs and natural products that have been shown to kill senescent cells in mice.
Metformin
Unity (biotech company)
Unity's method is based on targeting the biological pathways senescent cells use to resist the normal death of ageing cells. Inhibit the right pathway and death can be "nudged" to occur.