The History of Terrorism
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A priori
Analysis
Criticism
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Criticism of science
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Ernest Borek
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wikipedia
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1937-Today National Cancer Institute (NCI)
AMC Cancer Research Center
American microbiologists
American people of Hungarian-Jewish descent
Cancer researchers
City College of New York
City College of New York faculty
Colorado Regional Cancer Center
Columbia University Vagelos College of Physicians and Surgeons faculty
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Hungarian emigrants to the United States
People from Szabolcs-Szatmar-Bereg County
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University of Colorado Denver faculty
University of Denver faculty
Children
1962 In 1962, with Erwin Fleissner, Borek showed that methyl groups in RNA that are essential in various biological roles in coding, decoding, regulation, and expression of genes are introduced to RNA by methylating enzymes at the macro-molecular level.
1962 The first important break in this problem was reported by Dr. Fleissner and Dr. Borek in 1962 when they showed that the methyl groups became attached to...
1963 The existence of a pattern of methylation seemed all the more plausible as a result ot a discovery made last year by Dr. Srinivasan and Dr. Borek.
1963 Unified theory of cancer development
1964 NYT - Scientists Offer Unified Theory On Formation of Cancer Cells
1964 On March 22, 1964, The New York Times ran a page one article on a new unified theory of cancer development proposed by Borek and his Columbia University associate Dr. P. R. Srinivasan.
According to his concept, bulky methyl groups on certain bases along the nucleic acid chain might cause kinks and bends in genetically determined places on DNA and RNA molecules.
Borek's subsequent studies led to the discovery of DNA methylating enzymes as well.
Cancer Center's Support Review Committee of the National Cancer Institute
DNA methylating enzymes
Dr. Borek and Dr. Srinivasan believe that a single, universal chemical mechanism underlies the development of cancer.
Dr. Borek believes that they function at least in part to determine the three-dimensional, shape of nucleic acid molecules.
Dr. Borek's team has now shown, moreover, that none of the methylatable bases in one "breed" of RNA bears a methyl group, whereas a certain proportion of those bases...
He also served as director of the Colorado Regional Cancer Center and was chairman of the Cancer Center's Support Review Committee of the National Cancer Institute.
It is Dr. Borek's idea that this could be the monkey wrench that sabotages the normal protein factory and turns it into cancer.
It is the bases with methyl groups attached to them which Dr. Borek and Dr. Srinivasan believe are the key to the process of carcinogeuesis. Following, essentially, is an account of how their idea developed.
Ronald Kessler
This, according to Dr. Borek's notions, would destroy the distinctiveness of the cell's DNA and RNA-thereby probably upsetting the pattern of protein synthesis. What could come from this?
Thus, Dr. Borek feels, methy-' lated bases might give the DNA and RNA 'of each species their own distinctive shapes and in this way could help maintain the Individuality of a species.
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Ann M. Ryan
Elsie Wainfan
Erwin Fleissner
Lewis R. Mandel
Minuetta Kessler
P. R. Srinivasan (cancer researcher)