Elite Neutralizers
The main approach taken by research labs is to find people called “elite neutralizers” who have had COVID19 or been vaccinated (or both) but have an incredibly rare and unique response. These are people who can make very potent antibodies (called broad neutralizing antibodies; bnAbs) that bind to parts of the virus well beyond the spike protein—parts of the virus that are present in all of the coronavirus family, remain unchanged despite mutations, and are hidden (“cryptic” epitope sites). These elite neutralizer people are rare, but there’s basically a treasure chest of protection lying within them.