What is Perazine?

AI GENERATED FROM BRAVE SEARCH ENGINE:

Perazine is a moderate-potency, typical antipsychotic medication belonging to the phenothiazine class. It was first introduced in the 1950s and is primarily used for the treatment of schizophrenia and severe nausea and vomiting.

Mechanism of Action: Acts as a dopamine antagonist, particularly blocking D2 receptors, which helps reduce psychotic symptoms.
Key Characteristics:

- Suggested to have a lower risk of extrapyramidal side effects (movement disorders) compared to some other antipsychotics.
- Available in oral and intramuscular formulations for acute treatment.
- Used mainly in Germany, Poland, the Netherlands, and parts of the former Yugoslavia; not widely available globally.
Drug Class: Antipsychotics, antiemetics, antivertigo agents, phenothiazines.
Common Side Effects: Sedation, drowsiness, dry mouth, blurred vision, constipation, weight changes, and potential for neuroleptic malignant syndrome (NMS) or tardive dyskinesia with long-term use.
Contraindications: Hypersensitivity, CNS depression, blood dyscrasias, hepatic disease, coma, and subcortical damage.
Pregnancy & Lactation: Use during pregnancy or breastfeeding should be carefully considered due to potential risks to the fetus or infant; data is limited, and alternative agents may be preferred.

Note: Perazine is distinct from perphenazine, a closely related but different phenothiazine antipsychotic (brand name Trilafon), which is more widely available and used in many countries.

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Saturday, February 21, 2026 03:47PM

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