Parvalbumin

<p>Apr 27, 2010 1:40 PM

&#160;

good wiki article.

&#160;

A <b> Calcium &#160;binding albumin</b>. &#160;struc is similar to<b> calmodulin and troponin C</b>.

&#160;

localized in fast-contracting muscles and in brain.

&#160;

GABA-ergic interneurons... &#160;&#160;

&#160;

EF hand motifs bind Ca++

&#160;

expressed in chandeliers and basket cells in cortex

&#160;

In cerebellum &#160;PV expressed in Purkinjes.

&#160;

in HC &#160;PV+ internuerons are in many difft cells &#160;each subtype targeting distinct domains of pyrams.

&#160;

PV &#160;interneurons are mostly perisomatic.

&#160;

most are fast-spiking. &#160;&#160;thye give rise to gamma waves in EEG.

&#160;

PV interneruons repr abt 5% of GABA cells in primate DLPFC.

&#160;

Calretinin + &#160;cells are &#160;most abund subtype in DLPFC &#160;abt 50%.</p>