Deisseroth, Karl bio
<p>Dec 29, 2007 5:31 PM
 
EDAY talk - overview of his work at the lab.
Many great pdf's at his website.
 
Remote Control of Brains
C. elegans - tiny little nematode;  yellow lite it freezes
blue lite it contracts its head;  alternate lites ... looks like a work out video.
 
Psych. disorders extrem common:  depression 14%; alcohol 10%;  schizophrenia;  anxiety
 
he sees patients one day per week;
DBS in Parkinsons
 
 
Brain is a big electrical circuit;  make particular cell lite sensitive;
take some colored stuff out of flagella (get channelrhodopsin) and put it into neurons.
then shine with blue lite;  and put gene from algae into neurons;  use viral vectors to get
gene into rat neurons.
 
then put a promoter in front of the rhodopsin coding gene to turn it on and off.
 
 
 
 
 
see  Science pdf  Aug 2007 on Depression, animal model  ... impaired percolation.
 
Percolation is like water in a drip coffee maker.
uses voltage sensitive dye imaging  VSDI.
 
spreading of activation is like coffee.
 
there are newborn neurons in hippocampus.
chronic stress impairs neurogenesis.
 
Prozac,  all SSRI's promote neuron growth.
 
there is NO other bioengr. group anywhere involved in psychiatry (? at any university).
 
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