Huguenard Lab
<p>May 12, 2011 09:30 PM john.huguenard@stanford.edu</p>
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JOHN HUGUENARD, PhD</p>
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Thalamocortical synchrony and epilepsy..</p>
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We are interested in the neuronal mechanisms that underlie <b>synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system</b>. Such oscillations are <b>related to cognitive processes, normal sleep activities </b>and certain forms of epilepsy.
Our approach is an analysis of the <b>discrete components that make up thalamic and cortical circuits, and reconstitution of components into both </b><i><b>in vitro </b></i><b>biological and </b><i><b>in silico </b></i><b>computational networks</b>.</p>
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Accordingly, we have been able to identify genes whose products, mainly ion channels, play key roles in the regulation of thalamocortical network responses.</p>
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computer-based modeling of single cell and circuit behaviors
local perfusion of slice microregions
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