James Ferrell, Stanford, Bistability, Trigger Waves, and Coupled Oscillators in the Xenopus Embryo
<p>May 30, 2015 01:25 PM</p>
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open access; video from Stfd; 2013; audio + snippets of video and slides.</p>
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periodic syntehsis/ degrad of cycline drives the activation of CDK1 which drives mitotic entry and exit.
S-cyclin is an oscillator; from Pemerening in 2005 in Cell.</p>
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CDK1 is a master protein that control hundreds of other kinases.</p>
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shows the core oscillator circuit:</p>
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Cyclin leads to Cyclin-CDK1 which induces mitotic phosphorylations.</p>
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(all oscillators have neg feedback loops that damp them)</p>
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