Proteostasis Network
<p>Nov 24, 2016 07:40 PM</p>
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nice chart and explanation from Proteostasis Therapeutics (Cambridge Mass)</p>
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The PN ensures that <b>every protein within a cell will reach its final destination correctly folded </b>with appropriate function or be degraded and cleared to prevent damage. Disease, genetic mutations, environmental factors, and aging can cause the PN to become imbalanced, which can lead to a <b>decrease in protein quality control</b> contributing to diseases categorized as loss-of-function or gain-of-toxic function disorders. Loss-of-function diseases, such as cystic fibrosis, are often caused by inherited mutations resulting in inefficient folding and excessive degradation. Gain-of-toxic-function disorders, which include Alzheimer’s, Huntington’s, and Parkinson’s diseases, appear to arise from aggregation-associated toxicity.</p>
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