Active Dendritic Conductance migliore Shepard 2002

<p>Jan 03, 2016 09:12 PM</p>

<p>this is an exclt review;</p>

<p>see "At A Glance"</p>

<p>title Emerging &nbsp;rules for the distributions of active dendritic conductances...
Nat Rev Neurosci. &nbsp;2002.</p>

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<li>Studies in the past decade have provided data on the presence and <strong>distribution of voltage-gated ion channels in the dendrites</strong> of many types of neuron, but general rules that can explain their distribution are still missing. Uncovering these rules will be an important step towards a ,<strong>'functional proteomics' of nerve cells</strong> which will be essential in defining neuronal phenotypes.</li>

<li></li>

<li><strong>The properties of the dendritic tree have important implications for neuronal functio</strong>n.</li>

<li>But if dendrites were strictly passive, this would limit their ability to contribute to synaptic integration.&nbsp;</li>

<li>So, the <strong>presence of active conductances and their precise distributions profoundly modify the functional properties of the dendritic tree.</strong></li>

<li></li>

<li>The localization of at least <strong>four classes of voltage-gated ion channels &mdash; Na⁺, Ih, KAand Ca2⁺ channels</strong> &mdash; has been studied in a variety of cells from several brain regions, using both direct approaches and theoretical modelling. Channel distribution is often heterogeneous within a single neuron and across different cell types. A key goal is to explain the functional properties of each neuronal type as a function of this heterogeneity.</li>

<li></li>

<li>So far, attempts to account for specific neuronal phenotypes on the basis of channel distributions are in their infancy, but basic rules are beginning to emerge. More importantly, this type of analysis makes it possible to <strong>formulate specific predictions about neuronal function that depend on the channels that are found in the dendrites of a given cell </strong>&mdash; predictions that can be tested experimentally. Progress in this field will depend on obtaining more detailed information about the distribution of more channel subtypes in more types of neuron.</li>

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