2017 Reprogramming Beta Cells in Diabetes Cell Mirmira
<p>Feb 13, 2017 01:20 PM</p>
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cites new article in Cell Jan 2017.</p>
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loss of dysfunc of beta cells underlies ALL forms of DM.</p>
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still missing... attempt to regen endog. beta cells.</p>
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use 3 genes... converts exocrine into functiona beta cells...</p>
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artemisins...</p>
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GABA signaling as another method to augemnt formation of new betas.</p>
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3.5 fold incr in beta mass after 3 months of GABA rx.</p>
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new beta cells arose from alphas.</p>
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So... small molecs and hormones that target GABA can reprogram cells to become new betas.</p>
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Human Islet Research Network HIRN....</p>
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humanized mouse models</p>
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