2015 Scott Sternson interview Inscopix

<p>May 30, 2018 07:59 PM pub 2015;</p>

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6 mins only (longest interview of Scott on YouTube)</p>

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Neurobio of Motivation: &nbsp;&nbsp;feeding; thirst; fleeing; fighting; fear;</p>

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<b>AGRP neurons</b> &nbsp;(mice)

optogen stim of well-fed mouse; &nbsp;&nbsp;seeks food despite that.</p>

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AGRP &nbsp;=> turning OFF the unpleasant &nbsp;hunger sensation. &nbsp;&nbsp;(ie negative valence)

(rather than positive valance/ reward seeking)</p>

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ie AGRP stim => &nbsp;increase of the unpleasant feeling.

creates aversion to a favored food.</p>

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uses Inscopix &nbsp;qv.</p>

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long lens: &nbsp;implant into Arcuate nucleus; &nbsp;GCAMP6; then GRIM lens into it. 6 mm down.

96% of neurons &nbsp;REDUCED actiivity when the animal just SAW food.</p>

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unpleasant feeling of being in that hungry state.</p>

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