2012 Mayford Siegelbaum Kandel Synapses and Memory Storage Cold Spring Harbor

<p>Feb 15, 2014 05:51 PM</p>

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Mark Mayford (Scripps Res Instit)

Steven Siegelbaum and

Eric Kandel &nbsp;(Columbia)</p>

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from Cold Spring Harbor Perspectives in Bio... 2012 paper</p>

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recom to me by Ralph Merkle.</p>

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The synapse is the functional unit of the brain. During the last several decades we have

acquired a great deal of information on its structure, molecular components, and physiological function. It is clear that synapses are morphologically and molecularly diverse and

that this diversity is recruited to different functions. One of the most intriguing findings is that

the size of the synaptic response in not invariant, but can be altered by a variety of homoand heterosynaptic factors such as past patterns of use or modulatory neurotransmitters.

Perhaps the most difficult challenge in neuroscience is to design experiments that reveal

how these basic building blocks of the brain are put together and how they are regulated to

mediate the information flow through neural circuits that is necessary to produce complex

behaviors and store memories. In this review we will focus on studies that attempt to uncover

the role of synaptic plasticity in the regulation of whole-animal behavior by learning

and memory.</p>

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how does memory change with learning...</p>

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page 1: &nbsp;procedural mem in simple systems.</p>

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habituation, sensitiz and classical conditioning.

flexion in cats, &nbsp;eye blink in rabbits,

gill withdrawal in Aplysia.

honeybees, crayfis.</p>

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change in syan strength by modulat rel. of xmtr.</p>

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repeated shocks to tail of aplysia leads to incr cAMP and gene transcrip and protein synth that leads to

growth of new synapses.</p>

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page 3: &nbsp;Declarative Memory and HC</p>

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damage to MTL &nbsp;=> &nbsp;t major mem systems</p>

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Declarative needs &nbsp;HC&nbsp;</p>

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1971 &nbsp;freely moving rats &nbsp;single unit studies ... space aorund the animal.

place cells</p>

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1978 &nbsp;O'Keefe &nbsp;HC has cognit map...

HC is a multimodal integrator and mapmaker.</p>

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in humans &nbsp;HC map &nbsp;is a more genl integrator of mem-spec assocs.</p>

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LTP &nbsp;see review by &nbsp;Luscher and Malenka in 2012.</p>

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