GROSSMAN, Terry Cal Restriction Iron Mar 31 2012
<p class="MsoNormal" >GROSSMAN, Terry Cal Restriction Iron Mar 31 2012</p>
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1) CAL RESTRICTION
photo of Dali Lama..</p>
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(terry was a small town doc before starting his current clinic...
sounds like decr collab with Ray; still has small biz with Ray selling vist;
takes Lipitor 10 mg)</p>
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obesity decr longevity</p>
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study of 900,000 M and W bi of 23-24 assoc with greatest longev.</p>
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bmi 23-24, if 5'7" then 146 to 154...(i didn't get it off slide)</p>
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he likes Caloried Restriciton with the restriction...</p>
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he likes Metformin...</p>
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thanks to Jeremy Stone and Mark McCarty...</p>
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the Hellers wrote a book...</p>
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the carbohydrate concentration CC diet...
just eat all carbs at one time during the day...</p>
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thot abt Ramadan Diet... (just once during day)</p>
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Many benefits of CR are due to low insuline levels...</p>
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(bill andrews told me... cannot make payroll in 2 weeks...
burned thru 32M in capital... VCs are not interested, unles in human trials...
he said geron focuse don cancer and not regen med;
bill was there in early 90s...)</p>
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insulihmsg "store fat and do not burn fat"</p>
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CC diet ;</p>
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eat all your carbs in one 90 minute meal... say at supper
(fruit, rice, wine)</p>
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and then no carbs at bkfst and lunch...</p>
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salad tuna, chicken avocado at other times...</p>
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get low insulin levels most of the time ...</p>
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look at</p>
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<a href="www.catalyticlongevity.org">www.catalyticlongevity.org</a> his friend...put up that site...</p>
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he rally likes metformin...</p>
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most common drug for type 2 diabetes...</p>
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rarely causes low blood sugar...</p>
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people die from other drgs cuz of hypglycemia...</p>
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metformin... decr gluc abs from gi tract
inhibits gluc formation in liver
incr sensit and number of insulin receptors... incr periph glucose uptake
incr util of fatty acids
(actions of metformin)</p>
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type II DM</p>
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2012 estim 300M
estim to be 30M in 1985 !!!
26M american in the USA in 2012</p>
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age 65 27% have it</p>
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prediabetes: 79M Americans...</p>
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born in USA in 2000: 33% of men and almost 40% of women will devel DM2...
or was it pre-dm</p>
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sl: fasting blood sug > 85 incr cardiovas reisk by 40% !!!</p>
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his criteria</p>
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fbs> 125 = DM
fbs 100=124 prediab 3X cv risk
fbs 86-99 high normal 39% added cv risk
only 1 in 7people have bs < 85...</p>
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hispts GROSSMAN Wellness Center... His longevity patients</p>
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Antiaging potential of Metformin</p>
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Dr Vladimir Dilman in early 1970s...</p>
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spinder, SR see his paper on metformin... turns on genes..</p>
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metformin incr lifespan of mice...</p>
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metformin => diarrhea...</p>
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benefits are theoreteical (he takes it; but NOT demonstrated)</p>
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he says, begin with 1/2 of 500 mg tab once a day with meals, then bid
if tol, maintain 250 to 500 mg 2x/day</p>
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side effects are lessiwth time-release formulation...</p>
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metformin XR...</p>
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he says 39% of us iwth high blood sugar... shoudl take metformin!!</p>
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EXERCISE (new topic)</p>
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(Bill Andrews is an ultramarathon runner... has run a lot )</p>
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he is age 65 years...
can expect to live 12.7 years</p>
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if exercise thenexpect added 18.4 years extra...</p>
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london bus drivers vs ticket takers...
drivers much worsehealth than ticket takers...
*</p>
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punch it really hard and then rest!!! that's what works</p>
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look at kids, look at animals</p>
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runa round then rest...
get in greathape with 18 mins d day...</p>
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2 min of exertion then 1 min rest...
then 1:45 exertion (more exertion) 1:15 rest</p>
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gradual increase the exertion til the last time your really maxing out</p>
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whole thing is 18 minutes long</p>
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OR just do</p>
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30 seconds of max exercise the 90 secs of rest... and perform 6-9 cycles
MAXIMUM workout...</p>
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want to do str training also!!!</p>
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Sgtr Taining reverses hormone decline..</p>
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also do 18 min of str training...
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An aspirin a day...</p>
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ROTHWELL Lancet 21 March 2012</p>
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69,000 pts 34 trials</p>
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ASA reduced CV deaths by 37% !!
and reduced cancer by 15%</p>
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take a baby aspirin per day...</p>
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Univ of Oxford... same finding... big decrin cancer </p>
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but does incr bleed risk...</p>
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Seshasi Arch Int Med 2012... reduces ht attack , stroke..</p>
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Men age 45 to 80</p>
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not recom for anyone over 80...</p>
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take 81 per day day...
every other day is NOT effective...
nees to be done for 3-5 years...</p>
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*
IRON RX:</p>
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many os us have TOO MUCH IRON...</p>
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IRON uses in apoptosis... contribs to free radical formation..
and copper is bad also!!
do NOT take iron or copper under any circum...</p>
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FORTIFIED FOODS are bad.. inst oatmeal, cereals..</p>
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IRON v toxic... Ferritin to Fe3 to Fe 2...</p>
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free rads are corr r=0.76 with Ferritin...</p>
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only way to get rid of iron...</p>
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young women... bleed... huge health benefit..
he identifies it as cause of incr lifespan ..</p>
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TOM LEVY, MD iron excess ay be most overlooked major factor in chronic disease...</p>
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most labs say nromal range is 20 to 400 ng/ml (just means 2 sd are in that range)</p>
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IRON incr heart attack reisk in men</p>
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men with ferritin > 200 mics 2 fold risk of MI...</p>
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same with cartoid disease...</p>
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Toumainen 1997 study.. doante blood! big drop in dis risk.</p>
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also lower cancer risk...</p>
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Zacharski J NCI 2008 less cancer!!! double blind study...</p>
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hemochromatosis assoc with incr Alzheimers disease...</p>
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he says optimalrange is 12 tgo 25 (NOT 20 to 400)</p>
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if ferritin > 50 give blood.</p>
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he says its why women livelogner than men!!</p>
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mesnstruating women 25 to 35</p>
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menopasu age 50 to 59 ferr level 60
women > age 60 level 90 to100
Men avg 150 !!!!</p>
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NHANES III data</p>
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every pint of blood will drop ferr by 50...</p>
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shortcuts: CC diet; metformin exercise; ASA 81; donate blood</p>
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brad cottel: fructose? A HFCS is bad...</p>
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high intensity training does it cuz incr cortisol?</p>
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type DM2 = incr</p>
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he really likes testost. supplementation... most ocmmonly low in his pt..
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