2014 Encapsulate This

<p>Feb 18, 2015 09:15 PM &nbsp;&nbsp;Nat. Medicine review from Jan 2014... &nbsp;by Elie Dolgin

(in my pdfs);</p>

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Arturo Vegas;MIT; &nbsp;&nbsp;encapsulate in alginate (from seaweed)</p>

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become engulfed in scar tissue in two weeks (fibrotic)</p>

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Albert HWA... in charge of beta cell rx at JDRF.</p>

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alginate &nbsp;</p>

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2013 &nbsp;JDRF formed a consortium on encapsulation.</p>

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Vegas's team gor 9M from &nbsp;JDRF in 2007 and .8M from Helmsley;</p>

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they could retrieve all the capsules... they were clean and fibrosis free.</p>

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Dan Anderson and Langer... &nbsp;could cure mouse DM.</p>

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alginate with a few islets in each.</p>

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or islets onto protective hydrogel. &nbsp;Shapiro is direc of Edmonton islet transplant.</p>

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Shapiro i collab with Viacyte. &nbsp;&nbsp;JNJ also invested in viacyte.</p>

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Gordon Weir packing densities drive me crzy.</p>

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planar macro &nbsp;only 1000 iselts.</p>

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Encaptra &nbsp;24,000 islets.</p>

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Beta-O2 TEch: &nbsp;bockey pucl: &nbsp;alginated-impregnated Teflon that holds

two layers of iselts (each encap again in alginate microsphers separated by a central

chamber of oxyen.</p>

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Beta-O2 is filled with cadaveric islets &nbsp;into German pts: &nbsp;10 months laater

no signs of destroying clles insdie. &nbsp;the device is BetaAir support &nbsp;200K islets

says Avi Rotem &nbsp;&nbsp;CTO. &nbsp;device is 18 by 68 mm;</p>

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MIT Koch Instit: tiny beads made from alginate; &nbsp;E9 &nbsp;Anderson, Langer and assoc. &nbsp;teamed with Melton;

either 0.5 or 1.5 mm diam;</p>

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rat islets &nbsp;encaps with E9; &nbsp;after 10 months: nothing wrong with glucose

and few signs of fibrosis; &nbsp;planned LT studies in monkeys in 2014.</p>

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