Christopher Moore
<p>May 29, 2009 10:51 AM
 
talk at MBC yesterday in Munzer.
 
co-author on gamma oscil paper...  his lab did the work using Karl's optogenetics.
 
work done in mice  vibrissae  (whiskers).   mice whisk their environment.
 
behavioral dynamics of info acquisition  is important  (eg   saccades for eyes;  whisking in mice).
 
whiskers move at 5-10 hz.   short whiskers in front pointing str ahead;  long in back  pointing bkwd.
short whiskers have higher freq response and more spatial resolution  (just like cones);  periph whiskers
are slower and have lower spatial resolution.
 
S1 is the primary somatsensory cortex.  skin is obviously bigger than the surface area of the brain.
 
well known that the FS fast spiking interneurons create the gamma oscillations.
 
Astrocytes are wrapped around blood vessels and regulate the local blood flow...
it may be astrocytic activity that is reponsible for the BOLD signal increase that
is seen with incr. neural activity in fMRI.
 
they use  9 tesla MRI for their mice and do 2photon imaging.
 
neural activity induces blood blow
neural activity induces astrocyte activ which in turn induces blood flow
and all  bkwd links also.
 
They also use MEG on their human subjects  (300 detectors).
 
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