Phillips Chronic Microsensors Dopamine Subsecond
<p>Sep 30, 2010 7:37 PM
 
can detect the neuroxmtr DA  with subsecond time resolution over months in vivo in rats and mice
(and humans!!).
 
Mesencephalic DA systems are a primary focus of resch in motivation, and reinforcement learning...
get disruption inf Pksons, schizophrenia, subst abuse, and depression.
 
Electrochemical techniques,  such as fast-scan  cyclic voltammetry  FSCV  provides high
temporal resol and ability to discrim  from other electroactive species.
 
Microsensor is a 7 micron  carbon fiber ....  linear response to physio concentration of DA.
can get  response to   VTA stim  or to  reward delivery... look similar.
 
Delivery of natural reward has been shown to inct the firing of DA neurons in VTA and in substantia nigra
pars compact in monkeys  and  DA rel in Nuc Accum in rats.
 
FIGURE 3  key figure  XYZ plot  similar to what he showed in lecture.
 
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