SAMP8 MOUSE
<p>Dec 24, 2010 04:35 PM
 
enclosed is  Butterfiled and Poon pdf
 
from Experimental Gerontology  2005.
 
The<b> senescence-accelerated prone mouse (SAMP8): A model of
age-related cognitive decline </b>with relevance to alterations of the gene
expression and protein abnormalities in Alzheimer’s disease
 
SAM  was estab in 1981... characteristic learning and memory deficitis at old age.
Selective breeding was applied based on the degree of senescence, the lifespan, and
age-assoc pathologic phenotypes.
 
SAMP8 mice have charac. learning and memory deficitis at old age.
 
Look at Table 1:  they are  10 difft SAM strains...  all with difft deficits:
amyloidosis,  impaired immunity
 
degen arthirts
senile osteoporosis
age-depend amyloid
age-related cataracts
brain atrophy,  contracted kidney
cancers,  colitis.
 
incr oxidative stress
finding consistent with free radical theory of aging that posits the oxidative modification by reactive oxidative species (ROS).
 
Alterations in the permeability of the BBB blood brain barrier could contrib. to decline in energy metab in age SAMP8 brain.
 
This review indicates that oxidative stress is critic. important in these processes  and amyloid beta may play a signif role
in agre-rel cognit. decline.
 
 
 
 
 
 
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