2020 Thalamus Modulates Consciousness

<p>February 15, 2020, 1:01 PM</p>

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<p>in NEURON. &nbsp;Feb 12 2020.</p>

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<p>from U Wisconsin, Madison. &nbsp;online; open access;</p>

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<div class="ce-list--remove-bulletslist-itemtext">Central lateral thalamic stimulation arouses macaques from stable anesthesia</div>

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<li id="u0015" class="ce-list--remove-bullets__list-item"><span class="label">&bull;Thalamic</span>

<div class="ce-list--remove-bulletslist-itemtext">and deep-layer cortical spiking correlate with consciousness level</div>

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<li id="u0020" class="ce-list--remove-bullets__list-item"><span class="label">&bull;Consciousness</span>

<div class="ce-list--remove-bulletslist-itemtext">depends on feedforward, feedback, and intracolumnar signaling</div>

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<li id="u0025" class="ce-list--remove-bullets__list-item"><span class="label">&bull;Pathway-specific</span>

<div class="ce-list--remove-bulletslist-itemtext">signaling operates at alpha and gamma during consciousness</div>

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<h2 id="secsectitle0010" class="top" data-left-hand-nav="Summary"><span class="top__text">Summary</span></h2>

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<div class="section-paragraph">Functional MRI and electrophysiology studies suggest that consciousness depends on large-scale thalamocortical and corticocortical interactions. However, it is unclear how neurons in different cortical layers and circuits contribute. We simultaneously recorded from central lateral thalamus (CL) and across layers of the frontoparietal cortex in awake, sleeping, and anesthetized macaques. We found that neurons in thalamus and deep cortical layers are most sensitive to changes in consciousness level, consistent across different anesthetic agents and sleep. Deep-layer activity is sustained by interactions with CL. Consciousness also depends on deep-layer neurons providing feedback to superficial layers (not to deep layers), suggesting that long-range feedback and intracolumnar signaling are important. To show causality, we stimulated CL in anesthetized macaques and effectively restored arousal and wake-like neural processing. This effect was location and frequency specific. Our findings suggest layer-specific thalamocortical correlates of consciousness and inform how targeted deep brain stimulation can alleviate disorders of consciousness.</div>

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