Leptin
<p>Jan 12, 2011 10:53 PM</p>
<p>
leptin means THIN.</p>
<p>
16k Dalton protein hormone. plays a key role in 167 amino acids. (note: 100 to 1: each AA weighs about 100).
regulating energyintake and energ expenditure
including appetite and metabolism.</p>
<p>
Leptin is a STRONG appetite suppressant that, when deleted, causes
early onset, severe obesity in humans and animals.</p>
<p>
discovered by studing mutant obese mice. were voracious.
homozygous mice either ob/ob (mutated leptin) or db/db (mutated leptic receptor.</p>
<p>
When ob/ob are treated with leptin they lose their weight and return to normal.</p>
<p>
Synthesis: 167 amino acids; made in white ADIPOSE TISSUE and the level of
circulating leptin is directly proportional to the amount of fat in the body.</p>
<p>
Function:
Leptin acts on receptors in <b>hypothalamus</b> to INHIBIT APPETITE</p>
<p>
In March 2010</p>
<p>
</p>