STATINS and DIABETES Risk
<p>see popular rerporting of this important research in nodes below
(but ... just ONE study)</p>
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Oct 03, 2016 09:11 PM (recomm. by Karen M.)</p>
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target article is (Hanna) Cederberg... Markku Laako in</p>
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Diabetologia...</p>
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Incr risk of diabetes with statin treatment in METSIM cohort </p>
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accepted Jan 2015</p>
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Finnish study below: 50% incr risk of T2DM = type 2 diabetes in Statin takers.
<b> </b>
<b>ims/hypothesis </b><b>The aim of this work was to investigate the
mechanisms underlying the risk of type 2 diabetes associated
with statin treatment in the population-based Metabolic
Syndrome in Men (METSIM) cohort.</b></p>
<p>
Methods A total of 8,749 non-diabetic participants, aged
45–73 years, were followed up for 5.9 years. New diabetes
was diagnosed in 625 men by means of an OGTT, HbA1c
≥6.5% (48 mmol/mol) or glucose-lowering medication started
during the follow-up. Insulin sensitivity and secretion were
evaluated with OGTT-derived indices.
Results Participants on statin treatment (N=2,142) had a 46%
increased risk of type 2 diabetes (adjusted HR 1.46 [95% CI
1.22, 1.74]). The risk was dose dependent for simvastatin and
atorvastatin. Statin treatment significantly increased 2 h glucose (2hPG) and glucose AUC of an OGTTat follow-up, with
a nominally significant increase in fasting plasma glucose
(FPG). Insulin sensitivity was decreased by 24% and insulin
secretion by 12% in individuals on statin treatment (at FPG
and 2hPG <5.0 mmol/l) compared with individuals without
statin treatment ( p<0.01). Decreases in insulin sensitivity and
insulin secretion were dose dependent for simvastatin and
atorvastatin.</p>
<p>
Conclusions/interpretation<b>Statin treatment increased the risk
of type 2 diabetes by 46%, attributable to decreases in insulin
sensitivity and insulin secretion.</b>
Keywords 2-h glucose . Fasting glucose . HbA1c . Insulin
resistance . Insulin sensitivity . Statin . Type 2 diabetes<br />
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