2012 Dec Breakthrough: compound generated by low carb/low-calorie diet blocks effects of aging
<p>Dec 10, 2012 10:01 AM
 
KurzAI story  from SCIENCE;
 
1st author is (last name is Shimazu) Tadahiro Shimazu et al.  Suppression of Oxidative Stress by Beta-Hydroxybutyrate etc.  in lab of Eric Verdin at Gladstone at UCSF.
 
see Science article
 
last para of article:
 
Our observation that βOHB is an endogenous HDAC inhibitor present
in organisms at millimolar concentrations during <b>prolonged fasting and</b>
<b>CR reveals an example of integration between metabolic status and epi-genetic changes</b>.
 
 We show that changes in histone acetylation and gene
expression  caused by<b> βOHB promote stress resistance in the kidney.</b>
Future studies should investigate the specific gene expression and physi-ological effects
 of βOHB in other tissues. For example, <b>low carbohydrate</b>
<b>diets that induce significant ketogenesis are broadly neuroprotective and</b>
<b>enhance resistance of neurons to oxidative damage (20)</b>. In addition,
reduction in HDAC activity by either genetic manipulation or chemical
inhibition extends lifespan in  Drosophila(21,  22). <b>Inhibition of HDACs</b>
<b>by βOHB might contribute to the beneficial effect of ketogenic diets, and</b>
<b>may be one mechanism by which calorie restriction confers health bene-fits</b>.
 
see ref 20:
 
Y. Kim et al  Ketone bodies are protective against oxid stress in neocortical neurons
J Neurochem 101  1316 2007</p>