Frank, Loren UCSF Memory

<p>Mar 01, 2015 02:07 PM &nbsp;quite good &nbsp;2013... note in Vimeo &nbsp;(not in YouTube)

27 minutes.</p>

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retrieval reinstates patterns of activity assoc with initial experience.</p>

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(hearing rattlesnake, get out of there)</p>

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retrieval is rapid &nbsp;(remembering bkfst does not require the 45 mins that bkfst actually took)</p>

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NC &nbsp;cortex (outer rind); &nbsp;</p>

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HC &nbsp;one time only events...</p>

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NC &nbsp;slow plasticity: &nbsp;events that happened many times;</p>

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consolidation: &nbsp;HC broadcast &nbsp;out to the rest of the brain...</p>

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HC &nbsp;is critical to ability to retrieve that info &nbsp;(to reactivate from NC)</p>

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LFP &nbsp;summed activity &nbsp;&nbsp;5 to 10 hz rhythm</p>

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1971 &nbsp;John O'Keefe place cells;</p>

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great video recording, places &nbsp;corel. with &nbsp;firing of neurons.</p>

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at rest: &nbsp;in 80 ms &nbsp;get a burst of activity: &nbsp;SWR.

again, &nbsp;get cell 1, then 2, then 3.</p>

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discovered during sleep;</p>

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W track: &nbsp;alternate in-and-out of middle arm; &nbsp;if went R, go L &nbsp;etc.</p>

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replay when animal is at rest; &nbsp;&nbsp;switches into contemplative mode;</p>

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may be the fundamental mode of the HC... what happened to me;</p>

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we can detect in RT and interrupt SWRs.</p>

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ripple disruption really zaps learning.</p>

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