2013 Sulzer Visualizing Neurotransmitter Secretion at Individual Synapses
<p>Dec 04, 2016 06:53 PM</p>
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Columbia from Sulzer Lab; </p>
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FFN = fluor false NT's = neurotransmitters</p>
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To advance understanding of the brain, the ability to measure both nerve cell electrical spiking and chemical neurotransmission with high spatial resolution is required.</p>
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In comparison to the development of voltage sensors and Ca2+ indicator dyes over the past several decades, high resolution imaging of neurotransmitter (NT) release at single synapses has not been possible. </p>
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In this Viewpoint, we discuss two recent developments toward this goal, namely, the design of fluorescent false neurotransmitters (FFNs) and optical neurotransmitter sensors.</p>
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synapse is 1 micron in diameter.</p>
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one mm3 of gray matter has about 1 billion synapses;</p>
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