Orexin Hypocretin
<p>Aug 14, 2011 12:39 PM</p>
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Karl D. pronounces this hypo CREET in.</p>
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these peptides are produced in a very small pop. of cells in the
lateral and posterior hypothalmus, but send projections thruout the brain.</p>
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orexins = synonym for hypocretins.</p>
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strongly conserved ... found in all major classes of vertebrates.</p>
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Orexin promotes wakefulness. increases locomotion and energy expenditure.
should an animal be asleep or awake and active... (integrates metabolic, circadian and sleep debt)</p>
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Nov 15, 2013 06:44 PM
today (in Sleep Grand Rounds), Helmut Haas (Dusseldorf) says
Orexin/ Hypocretin system is the orchestra conductor (of sleep) but
the Histamine system is the first violin. see TMN = tuberomammillary nucleus.</p>
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