Thile Halcyon Molecula Bankrupt Andregg
<p>Jun 25, 2011 07:14 PM  located at 505 Penobscot Drive  RWC 94063
 
650  388-0725
 
HALCYON MOLEC
 
Board of Direcs:  William Andregg founder with his brother  Michael Andregg
ANDREGG invented Halcyon's core polymer placement technology.  two brothers
 
Luke Nosek  co founder of PayPal
 
Peter Thiel  managing partner of Founders Fund....  Clarium Capital;  first ext investor in Facebook;
Thiel Foundation
 
 
Elon Musk  co founder of PayPal, SpaceX and Tesla Motors.
 
Tesla... first production auto to use lithium-ion batteries.
 
Advisors:  <b>George Church</b>;  Steve Pennycook;  <b>Dean Toste </b>Cal Berk; <b>Ron Davis</b>  Stfd  Dir of Stfd Genome Tech Center
and others
 
Read their essay:  the IMPORTANCE OF LONG READS  under technology;
current tech can only do reads of only a few thousand bases at best...
 
a full genome has never been sequenced;
 
Below are more notes for ANDREW BLELOCK TALK at FS Google
ANDREW BLELOCK    Cambridge, Engl
joined Halcyon Molec
1961  Feynman ....   alll things are made of atoms  (most important single msg of science)
plenty of room at the bottom... Feynman... the start of nanotech...
just look at the thing  (make electron  microscope a 100X more powerful)
So, to sequence DNA, usual method is to amplify by PCR...
then chop it into tiny pieces and sequence each piece then put them together...  (to seq DNA)
some cancer genomes carry > 100,000 point mutations
10-8 mistakes (mutations in DNA)  ie  1 part in 100 million error rate.  so, very tiny error rate in replic  DNA
need straight DNA is required to convert position to code...
can label DNA with single heavy atoms and then just read it out...
molec threader...
dip needle into solution with DNA  and pull out dna onto substrate...
hollow needle, drop and substrate...
pdmf is the substrate....
stretch out dna to 10 to 20 microns
(usual is perhaps only 200 bp  and is less than one micron
labeled dna with single heavy atoms
electron microscope  visualizes single objects... you do NOT want an ensemble
best electron lens available in the 1990s  like making a light microscope out of a wine glass..  wicked spherical aberration....
"glasses for the EM"
aberration correction was described in 1947 but only
achieved in 1997...
the "glasses" are 500k dollars each....
STEM produces one pixel... that's why u need to scan
nature nanotech dec 2000  surely you're happy  doctor feynman  .... describes this development
of new  EM.
 
 
 
 
 
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