HeartFlow FFR Discover-Flow
<p>Feb 21, 2012 02:17 PM  (developed by Charlie Tayor, PhD  Stfd and Chris Zarins, MD Stfd... 15 yrs of resch);
 
totally cool!  (from Martin Blum)
also see discussion by Bill Fearon today at CVI talk at noon.
 
non-invasive computation of FFR = fractional flow reserve =
 
 pressure in artery /  aortic pressure.
 
but they call it  FFRct  (derived from CT scan data)
provides lesion-specific FFRct values.
 
r value of 0.73 btwn non-invasive FFRct and invasive FFR data.
 
best way to guide treatment for CAD.
 
where does signif reduced risk of death or MACE come from?
(answer from Bill Fearon:  NOT placing unneeded stents and
NOT doing CABG when stents will do:  also  NOT placing
stents at all when medical rx is all that is needed.)
 
see graph:  from Koo, Bon_kwon from DISCOVER-FLOW trial  in 2011
 
CCTA  massively OVER-READS lesions;  FFRct gets rid of false +s
knocks them down from 38% down to 11%  YES!
 
DISCVOER-FLOW baseline:   age 63; 72% male;  bmi 26;
55% had LAD lesions
 
Results from<b> HeartFlow’s first multicenter study (DISCOVER-FLOW) </b>were published in the <em>Journal of the American College of Cardiology</em> (JACC) in November 2011. DISCOVER-FLOW was a prospective multicenter study to determine the diagnostic performance of FFR<sub>CT</sub> compared to measured FFR at the time of <b>invasive coronary angiography (ICA)</b> in patients with suspected or known coronary artery disease (CAD). <b>FFR</b><sub><b>CT</b></sub><b> was performed on 159 vessels in 103 patients undergoing coronary computed tomographic angiography (CCTA), ICA, and FFR</b>.
<b>FFR</b><sub><b>CT</b></sub><b> led to a 70% reduction in false positives and 25% improvement in per-vessel diagnostic accuracy when compared to CCTA.</b> For more information, please click the thumbnails below.
 
 
 
 
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