PPARGC1A PGC1a alpha
<p>May 26, 2015 09:43 PM</p>
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PPAR gamma coactivator 1 alpha abbrev PGC1a. is a protein.</p>
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it is a transcriptional coactivator that regs the genes involved in energy metabolism</p>
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it is a regul of MTs = mitchondria biogenesis and func.</p>
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it interacts with the nuclear recp PPAR gamma that permits interac with multiple TFs.</p>
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can regulate cAMP response element binding protein CREB and also NRFs (nuclear regul factors)</p>
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controls BP, regul cellular choles homeostas and obesity.</p>
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note: clin signif section here is very positive but note great lecture by Zoltan Arany today:
PGC1a can be BAD!!! (it unregs FFA transport!, so can get too much fat stored in myocytes)</p>
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see last sentence...</p>
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