VLAB Longevity, June 21, 2016
<p class="MsoNormal" >VLAB Longevity
This is a VLAB symposium on Launching Longevity at SRI tonite
June 22, 2016.</p>
<p>
many excellent panelists
(two keynotes: 1) Aubrey de Grey and 2) Daniel Kraft.</p>
<p>
host is Sonia Arrison.. (new book)</p>
<p>
Sonia asks a Q
what is a longevity company</p>
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Brian Kennedy...answers.... he is Direc of
Buck Instit for Research on Aging...
dx or intervention side.</p>
<p>
Will Eden (Theil Capital)
maybe even <b>extending max lifespan</b>...
to fit into Aubrey's framwork
try to halt or reverse accumulation of damage..
eg lots of failure of amyloid hypothesis... what's going on?</p>
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Brian K: hard to separate longevity and metabolism.
(responding to Aubrey's notion that metab is too difficult to crack)</p>
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hard to separ tor, insulin IGF etc.</p>
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is healthspan a tradeoff with lifespan NO says Aubrey...
<b>healthspan confers lifespan</b>...</p>
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Sonia... is there something to invest in with a goal of 8 to 10 years...</p>
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Tom Rando... NO! this is really LT...research with LT payoff.
where the sweet spot btwn VCs and biologists.</p>
<p>
where is the sweet spot... the low hanging fruit...</p>
<p>
<b>Joe McCracken</b>...
<b>Alkahest</b>
he is a DVM, and VP of biz dev ...
they bot out their seed investors! so promising is this!</p>
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got 37M in equity investment...</p>
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has 5 to 6 years of cash...
did the basic sci ten years ago.</p>
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need angel investment or philanthropy..</p>
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Alkahest... check it out... what is it...</p>
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is there IP? how to protect your investment... (see Guardian article: parabiosis)</p>
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this is a panel...</p>
<p>
BK = Brian Kennedy...</p>
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lots of perverse incentives to do sickcare rather than preventative care.</p>
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resveratrol or metformin how to do that and get it thru FDA
(DK daniel kraft calls it the f word)</p>
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what are the biomarkers of aging...
Novartis: studied everolimus... for aging.</p>
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and want to do healthspan study of metformin...
think that metformin will delay the 2nd chronic disease... only a 5 yr study... interesting study.
can metformin delay any 2nd chronic disease.</p>
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we really need preventative medicine.. a whole panoply of interventions...
that are pre-symtomatic...</p>
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tom rando... we do do pre sx rx like rx BHP = hypertension.</p>
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sarcopenia.. (tom continues)... they will be a disease as soon as we can rx it</p>
<p>
(same as osteopenia... we now have rxs)</p>
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FDA is good, says Tom.. prevents hucksters.</p>
<p>
*
takes Qs on her ipad... tweeted in...</p>
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how many of panelists... take seriously the notion of extending life to 150 years...</p>
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as we address healthspan then lifespan will increase.</p>
<p>
goal is to incr healthspan</p>
<p>
Joe McCracken...
our comp. was healthspan to be extended.
but we do have a moonshot project.
<b>a biomarker of aging</b>... probably many proteins.
prob. many proteins.
why do they advance at difft rates.</p>
<p>
Will Eden...
drugs good at extending median healthspan but
nothing in physics to prevent age 150...he guesses.</p>
<p>
want healthy max lifespan extension...</p>
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Dan Kraft Calico, gather genomes fron centanarians.
we want sharp cognition at 120.
do eye tracking for dementia.</p>
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BK... healthspan is a more coherent argument...</p>
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interventions in mice do work says Brian K... <b>do extend max lifespan.</b></p>
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huge audience response to how many want to live to 150...majority in our audience.</p>
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BK wants to be bored at the age of 150 and not demented at age 80...</p>
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Aubrey... may get escape velocity....</p>
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Sonia...
aud Q how abt massive simulation of human body to simulate the entire thing
Will Eden: NO! can't even do one protein in a folding model.</p>
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DK data collection... what do u do with all that data... how to make ti actionable.
eg a statin... look at pharmacogenetics... important for statin metabolism.</p>
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want to get VS in the field.</p>
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Lee Hood involved in this...</p>
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eat less and be more active says tom rando...
easy but people do NOT do it even tho its easy.at </p>
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Aubrey the magnitude of benefit is not v great...</p>
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look at USA vs Japan... we spend huge amts in USA and get nothing</p>
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Japan... they eat less... 5 year diff btwn USA and Japan!</p>
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can we really mount a strong argument against it... say for drinking and eating...</p>
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yes u can for smoking...and saving for retirement says Tom Rando...</p>
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people are bad ... at making LT decisions</p>
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*</p>
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lets do rapid fire...</p>
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bio FICO score...</p>
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epigenetic clock says tom rando... lots of people doing it.
(tom really believes in the power of epigenetics.. lifestyle to modigy genetic expression)
lots of work doing that..</p>
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how big a role does CR play...</p>
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it works in MICE says Joe McCracken.</p>
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extend life of rodents by 50% (this was initially done perhaps 80 yrs ago.)</p>
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but CR works less in people that are already long lived...</p>
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who should do moonshot projects...? (that take ten years or more)
Will... do other than VCs... should high net worth.. people ; or corporate VCs
tens of billions; soverign wealth funds. huge issue.
better than VCs...
.
DK will go to Whitehouse cancer conference (Biden conf) on CA moonshot...</p>
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mental health... depression is a big driver of unhealthy choices</p>
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best to give them hope... give them a plan...</p>
<p>
next Q: supplements:... you don't know what's in the supplement
because now it's caveat emptor.
fish oil and vit E perhaps work says DK...</p>
<p>
what is Calico research revealing? can't say... stealth..</p>
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