AMYLOID beta A-beta
<p>Mar 12, 2013 09:25 PM A-beta = amyloid-beta</p>
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Joe Rogers thinks that beta amyloid is far better proven that TAU as initiating factor.</p>
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APP = amyloid precursor protein.</p>
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Abeta denotes peptides of 36 to 43 AAs. :
main components. of deposits in AD. = alz dis.</p>
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Peptides result from APP = amyloid precursor protein, which is cut to yield Abeta.</p>
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Abetas can aggregate soluble oligomers;
misfolded oligomers (known as seeds) can induce other Abeta to misfold (like a prion).</p>
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plaques are a tangle of ordered fibrillar aggregates called amyloid fibers.</p>
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Tau is another protein that can form prion-like misfolded oligomers.</p>
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secretases generate Abetla from APP</p>
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