Phosphatidylcholine for Ulcerative Colitis Stremmel Annals IM Nov 2007
<p class="default">07:02 PM, November 10, 2007 
 
Stremmel et al; Phosphatchol for Steroid-Refract Chronic Ulcerative Colitis. 
An Int Med 6 Nov 2007. 
 
A huge difference in this RCT btwn rx and control. 
 
This study may be hugely important to me. 
PC had a huge effect in these patients. 
I 
 
Key sentence  <b>:</b> <b>An insufficient level of phosphatidylcholine</b> 
 <b>in colonic mucus is a possible pathogenetic factor for ulcerative</b>  
colitis.  
 
RCT with 60 patients: PC dose 2 grams per day (given QID for 12 weeks. 
Huge diff. in outcome. 
 
A new therapeutic strategy with phosphatidylcholine 
supplementation in the colonic mucus has been developed. 
It is based on the pathogenetic concept of a mucosal barrier 
dysfunction in ulcerative colitis caused by a primary lack of 
the mucoprotective phosphatidylcholine in colonic mucus 
(1- 4). Because ingestion of phosphatidylcholine leads to 
complete absorption in the upper intestine and topical rectal 
applications of phosphatidylcholine do not integrate into 
the mucus, phosphatidylcholine was encapsulated with Eudragit- 
S100 (Ro�hm Pharma, Darmstadt, Germany) to provide 
pH-dependent release in the distal intestine (5).  
 
ghghg </p>