Matrine
Wikipedia:
Matrine is an alkaloid found in plants from the genus Sophora. It has a variety of pharmacological effects, including anti-cancer effects, as well as κ-opioid and μ-opioid receptor agonism.
Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities. Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait.
Mu opioid agonism is associated with euphoria, while kappa opioid agonism is associated with dysphoria and psychotomimetichallucinations (as seen in the kappa-agonist Salvinorin A). Both receptors are known to produce analgesia when activated.
Matrine and the related compound oxymatrine have an antifeedant effect against formosan subterranean termite. Additionally, it acts as a nematicide against the pine wood nematode which causes pine wilt, as well as pathogenic nematodes which target humans
ARTICLES/STUDIES
Anticancer effects of the chinese medicine matrine on murine hepatocellular carcinoma cells
Therapeutic effects of matrine on primary and metastatic breast cancer.
Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo