Mitraphylline

Mitraphylline is a non-narcotic alkaloid found in the leaves of the kratom tree (Mitragyna speciosa) and the bark of the cat's claw plant (Uncaria tomentosa). It's used to treat:

• Arthritis
• Heart disease
• Cancer
• Other inflammatory diseases

Mitraphylline is an oxindole derivative with the formula C21H24O4N2. It contains a carbomethoxyl group and two chromophores. When hydrolyzed, it produces mitraphyllic acid.

Mitraphylline has been reported to have strong anti-inflammatory activity. It's also been shown to modify the inflammatory response. It has anti-inflammatory effects by inhibiting the release of interleukins 1α, 1β, 4, 17, and TNF-α .

Anti-inflammatory activity of Mitraphylline isolated from *Uncaria tomentosa* bark

Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from *Uncaria tomentosa* bark on human Ewing’s sarcoma and breast cancer cell lines. 

Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of *Uncaria tomentosa* on human glioma and neuroblastoma cell lines.