Sesamolin

See also: Hydroxycinnamic acids / Phenylpropanoids ; Lignans

Sesamolin is a lignan isolated from sesame oil. Sesamin and sesamolin are minor components of sesame oil. It reduces the activation of p38 MAPK.

• Sesamin, sesamolin and the origin of sesame
• Recovery of Sesamin, Sesamolin, and Minor Lignans From Sesame Oil Using Solid Support-Free Liquid–Liquid Extraction and Chromatography Techniques and Evaluation of Their Enzymatic Inhibition Properties
• Variation of sesamin, sesamolin and tocopherols in sesame (Sesamum indicum L.) seeds and oil products in Thailand
• Sesamin and sesamolin: nature's therapeutic lignans
• Sesamolin attenuates kidney injury, intestinal barrier dysfunction, and gut microbiota imbalance in high-fat and high-fructose diet.
• Effects of sesamol, sesamin, and sesamolin extracted from roasted sesame oil on the thermal oxidation of methyl linoleate
• Pyrethrum synergists in sesame oil. Sesamolin, a potent synergist
• Drought stress influenced sesamin and sesamolin content and polyphenolic components in sesame (Sesamum indicum L.) populations with contrasting seed coat …
• Sesamin, sesamolin, and sesamol content of the oil of sesame seed as affected by strain, location grown, ageing, and frost damage
• Using Turmeric Oil as a Solvent Improves the Distribution of Sesamin‐Sesamolin in the Serum and Brain of Mice
• Sesamin and sesamolin as unexpected contaminants in various cold-pressed plant oils: NP-HPLC/FLD/DAD and RP-UPLC-ESI/MSn study

Cancer

• These results suggest that sesamolin induces apoptosis in HCT116 cells.
• Sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells
• Sesamolin enhances NK cell lysis activity by increasing the expression of NKG2D ligands on Burkitt's lymphoma cells
• Growth inhibitory effects of sesamolin from sesame seeds on human leukemia HL-60 cells

Hepatoprotective

• Sesamolin inhibits lipid peroxidation in rat liver and kidney
• Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats

Immune System Effects

• Sesamolin promotes cytolysis and migration activity of natural killer cells via dendritic cells.

Liver Effects

Comparative study of sesame lignans (sesamin, episesamin and sesamolin) affecting gene expression profile and fatty acid oxidation in rat liver.

Neuroprotective

• Neuroprotective effects of sesamin and sesamolin on gerbil brain in cerebral ischemia.
• Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells
• Oxidative Toxicity in BV‐2 Microglia Cells: Sesamolin Neuroprotection of H2O2 Injury Involving Activation of p38 Mitogen‐Activated Protein Kinase

Osteoporosis

Sesamolin showed promise as a new treatment for postmenopausal osteoporosis.

Skin Effects

• Inhibition of two stages of melanin synthesis by sesamol, sesamin and sesamolin
• Inhibitory Effect of Sesamolin on Melanogenesis in B16F10 Cells Determined by In Vitro and Molecular Docking Analyses