4. Biosynthesis and Degradation of Nucleotides

De Novo Purine Nucleotide Synthesis Begins with PRPP

Purine Nucleotide Biosynthesis Is Regulated by Feedback Inhibition

Pyrimidine Nucleotides Are Made from Aspartate, PRPP, and Carbamoyl Phosphate

Pyrimidine Nucleotide Biosynthesis Is Regulated by Feedback Inhibition

Nucleoside Monophosphates Are Converted to Nucleoside Triphosphates

Ribonucleotides Are the Precursors of Deoxyribonucleotides

Thymidylate Is Derived from dCDP and dUMP

Degradation of Purines and Pyrimidines Produces Uric Acid and Urea, Respectively

Purine and Pyrimidine Bases Are Recycled by Salvage Pathways

Excess Uric Acid Causes Gout

Many Chemotherapeutic Agents Target Enzymes in Nucleotide Biosynthetic Pathways