1. Biosynthesis of Fatty Acids and Eicosanoids

Malonyl-CoA Is Formed from Acetyl-CoA and Bicarbonate

Fatty Acid Synthesis Proceeds in a Repeating Reaction Sequence

The Mammalian Fatty Acid Synthase Has Multiple Active Sites

Fatty Acid Synthase Receives the Acetyl and Malonyl Groups

The Fatty Acid Synthase Reactions Are Repeated to Form Palmitate

Fatty Acid Synthesis Is a Cytosolic Process in Most Eukaryotes but Takes Place in the Chloroplasts in Plants

Acetate Is Shuttled out of Mitochondria as Citrate

Fatty Acid Biosynthesis Is Tightly Regulated

Long-Chain Saturated Fatty Acids Are Synthesized from Palmitate

Desaturation of Fatty Acids Requires a Mixed-Function Oxidase

Eicosanoids Are Formed from 20- and 22-Carbon Polyunsaturated Fatty Acids

BOX 21-1 Oxidases, Oxygenases, Cytochrome P-450 Enzymes, and Drug Overdoses