4. Cholesterol, Steroids, and Isoprenoids: Biosynthesis, Regulation, and Transport

Cholesterol Is Made from Acetyl-CoA in Four Stages

Cholesterol Has Several Fates

Cholesterol and Other Lipids Are Carried on Plasma Lipoproteins

HDL Carries Out Reverse Cholesterol Transport

Cholesteryl Esters Enter Cells by Receptor-Mediated Endocytosis

Cholesterol Synthesis and Transport Are Regulated at Several Levels

Dysregulation of Cholesterol Metabolism Can Lead to Cardiovascular Disease

Reverse Cholesterol Transport by HDL Counters Plaque Formation and Atherosclerosis

Steroid Hormones Are Formed by Side-Chain Cleavage and Oxidation of Cholesterol

BOX 21-2 The Lipid Hypothesis and the Development of Statins

Intermediates in Cholesterol Biosynthesis Have Many Alternative Fates