Nsp15

pmid: 33357040

a hexamer consisting of a dimer of trimers with endoribonuclease activity that preferentially cleaves immediately 3’ of uridines.

All characterized EndoU family members show an RNA endonuclease activity producing 20 ,30 -cyclic phosphodiester linkage and 5’-hydroxyl ends

Nsp15 inhibitors to cultured cells at different stages of coronavirus infection reduces the infectivity of SARS-CoV

responsible for protein mediate innate immune sensing and delays activation of the host immune response - the mechanism of nucleic acid immunity is unknown.

EndoU is to cleave polyU sequences from 5’ -polyU-containing negative sense (PUN) RNAs, thus limiting the formation of a pathogen-associated molecular pattern (PAMP) and blocking the ability of specific cytoplasmic PRRs to activate the response of innate immune to infection

pmid: 33635931

inhibits the formation of stress granules