SARS-CoV2 - Triple Helix (VirusTriplex)

Project name: VirusTriplex

The RNA of the virus could enter the nucleus (with the help of N) and bind to the genomic DNA and regulate gene expression.

• sites in the cov genome and corresponding tts in the human genome
• gene expression effects of cov2 infection. correlation with cov2-tfo’s
• tfo transfection. is there an effect on the genes?
• is the cov2-RNA and N in the nucleus
• mutation of the virus and check the effect
• is there a correlation for other RNA viruses?

1. test the concept
2. mechanistical questions

project start: 4-23 Fabian+Sabrina