hCoV229E - transcriptomic changes

(pmid: 33630927 2021)

HCoV-229E-infected MRC-5 cells - marked downregulation of super pathway of cholesterol biosynthesis and eIF2 signaling pathways. upregulation cyclins, cellcycle control of chromosomal replication. downregulation cellcycleG1/S checkpoint.

early upregulation of the antiviralresponse factor ApolipoproteinB, mRNA editingenzyme catalyticsubunit3B (APOBEC3B)

expression of genes involved inantiviral response 82% were downregulatedat 6 HPI,and 65% were downregulated 24HPI.