INC CRITERIA

Inclusion Criteria (Select).

Participants must:

• Be ≥18 years old with confirmed GPA or MPA per CHCC definitions.

• Be newly diagnosed or relapsing, requiring cyclophosphamide (CYC) or rituximab (RTX).

• Have positive anti-PR3 or anti-MPO antibodies (historic or current).

• Exhibit at least:•

1 major BVAS item, or• 3 non-major BVAS items, or•

Both renal items: proteinuria and hematuria.

• Have an eGFR ≥15 mL/min/1.73 m².