Proteome
<p>The <b >proteome</b> is the entire set of <a href="https://en.wikipedia.org/wiki/Protein" title="Protein" >proteins</a> expressed by a <a href="https://en.wikipedia.org/wiki/Genome" title="Genome" >genome</a>, cell, tissue, or organism at a certain time. More specifically, it is the set of expressed proteins in a given type of cell or organism, at a given time, under defined conditions. The term is a blend of <i >proteins</i> and <i >genome</i>. <a href="https://en.wikipedia.org/wiki/Proteomics" title="Proteomics" >Proteomics</a> is the study of the proteome. </p>
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In May 2014, a draft map of the human proteome was published in <i ><a href="https://en.wikipedia.org/wiki/Nature_(journal)" title="Nature (journal)" >Nature</a></i>. This map was generated using high-resolution Fourier-transform mass spectrometry. This study profiled 30 histologically normal human samples resulting in the identification of proteins coded by 17,294 genes. This accounts for around 84% of the total annotated protein-coding genes.</p>
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<img src="/567a96f0-9dee-5fd9-a5b2-dcfe98cbf4f1.png"/> <img src="/fba98bae-4d9d-5a2d-9211-e1d92bf829ee.png"/></p>
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<img src="/eff4d427-0a6b-56a2-ae63-1a5ca0dcb513.png"/> </p>
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<b>The Human Protein Atlas</b>
The Human Protein Atlas is a Swedish-based program initiated in 2003 with the aim to map all the human proteins in cells, tissues and organs using integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. The Human Protein Atlas consists of six separate parts, each focusing on a particular aspect of the genome-wide analysis of the human proteins; the Tissue Atlas showing the distribution of the proteins across all major tissues and organs in the human body, the Cell Atlas showing the subcellular localization of proteins in single cells, the Pathology Atlas showing the impact of protein levels for survival of patients with cancer, the Blood Atlas, the Brain Atlas and the Metabolic Atlas. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human biology and disease and it is selected by the organization ELIXIR (www.elixir-europe.org) as a European core resource due to its fundamental importance for a wider life science community. The Human Protein Atlas consortium is mainly funded by the Knut and Alice Wallenberg Foundation.
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