Glyceryl octyl ascorbic acid
Glyceryl octyl ascorbic acid (GO-VC) is an amphipathic derivative of vitamin C, consisting of two ether linkages: a 1-octyl at position 2 and a glycerin at position 3[1]. It is considered a new stable amphipathic vitamin C derivative in the field of aesthetic medicine, offering improved stability over conventional vitamin C derivatives[1].
Stability and Advantages
GO-VC improves the stability of conventional vitamin C derivatives, eliminating the problems of prooxidants. It has a high moisturizing power due to the binding of glycerin, preventing skin dryness. Additionally, GO-VC has sterilizing activity against many bacteria[1]. It is well absorbed percutaneously due to its amphiphilic nature and can facilitate percutaneous absorption with an iontophoresis device. GO-VC does not have a lipid group, reducing skin toxicity problems due to lipid peroxidation, and it does not have the sticky feeling of conventional vitamin C derivatives[1].
Acne Treatment
GO-VC has been reported to be effective against post-inflammatory hyperpigmentation (PIH), post-inflammatory erythema (PIE), and atrophic scar (AS), which are important complications in acne[1]. A clinical trial applied a complex vitamin C derivative lotion containing GO-VC to patients with acne, resulting in a marked improvement in PIH, PIE, and AS after 3 months[1].
Production and Use
A patent describes the production method and use of high-purity glyceryl octyl ascorbic acid derivative, which hardly generates ascorbic acid radicals[2]. Another source provides information on 3-glyceryl ascorbate, a novel, stabilized vitamin C derivative produced by binding vitamin C to glycerin, which has enhanced moisturizing and antioxidant properties[3]. A clinical trial using glyceryl-octyl-ascorbic acid/ascorbyl 2-phosphate 6-palmitate/DL-α-tocopherol phosphate complex treatment has been conducted for acne treatment[4]. The chemical structure and properties of glyceryl octyl ascorbic acid are also available[5].
Citations:
[1] https://en.wikipedia.org/wiki/Glyceryl_octyl_ascorbic_acid
[2] https://patents.google.com/patent/JP6589218B2/en
[3] https://www.makingcosmetics.com/VIT-GLYCASC-01.html?lang=en_US
[4] https://pubmed.ncbi.nlm.nih.gov/31149741/
[5] https://pubchem.ncbi.nlm.nih.gov/compound/54588053